LHX3

Across TCGA patient cohorts, LHX3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,354 significant associations in total. LGG shows the largest number of these associations.

The most reproducible LHX3-associated GO terms across cancer lineages are Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), Cell fate specification involved in pattern specification, and Base-excision repair, gap-filling. Each is linked with LHX3 in more than 9 cancer types. Because this analysis shows association rather than direction, both LHX3-to-partner and partner-to-LHX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) grouped by LHX3-low versus LHX3-high in TGCT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX3→partner) and Y-score (partner→LHX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.048	+0.578	<.001	<.001	3	10
STAD	Cell fate specification involved in pattern specification →	-0.111	-0.084	<.001	.002	2	9
STAD	Base-excision repair, gap-filling →	+0.057	+0.130	<.001	<.001	3	8
STAD	Regulation of DNA-directed DNA polymerase activity →	+0.080	+0.165	<.001	<.001	2	9
STAD	Obsolete nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' →	+0.050	+0.105	<.001	.002	2	8
STAD	7-methylguanosine cap hypermethylation →	+0.034	+0.096	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,354 associations by consensus.

Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) by LHX3 expression — TGCT

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