LHX3

Across TCGA pan-cancer cohorts, LHX3 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of LHX3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where LHX3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LHX3 is over-expressed in tumor, although a few such as CHOL show the opposite, repressed pattern.

COAD, HNSC, and BRCA are the cancer types where LHX3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LHX3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	IV	+0.065	.005	5	view →
HNSC	All	All	+0.249	.010	4	view →
BRCA	All	All	+0.010	.005	4	view →
LIHC	All	All	+0.400	.003	3	view →
LUAD	Female	All	+0.039	.016	2	view →
LUSC	All	II,III,IV	+0.031	.003	2	view →
PRAD	All	All	+0.006	.049	2	view →
CHOL	Female	All	−0.026	.001	1	view →
STAD	All	II,III,IV	+0.026	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

LHX3–COAD

Open the COAD breakdown →