LHX3

Across TCGA patient cohorts, LHX3 protein abundance is significantly associated with the RNA expression of many other genes, with 1,180 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LHX3-associated genes across cancer lineages are CYTH4, NCF4, and CSF2RB. Each is linked with LHX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LHX3-to-partner and partner-to-LHX3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LHX3 versus CYTH4 in LSCC, with a Pearson correlation of 0.57.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX3→partner) and Y-score (partner→LHX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CYTH4 →	+1.040	+0.617	<.001	.001	3	1
LSCC	NCF4 →	+0.927	+0.622	<.001	<.001	3	1
LSCC	CSF2RB →	+1.047	+0.557	<.001	.001	3	1
LSCC	RANGAP1 →	-0.748	-0.853	<.001	.003	3	1
LSCC	YY1 →	-0.645	-0.598	.003	.003	3	1
LSCC	CCNB1IP1 →	-0.957	-0.602	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,180 associations by consensus.

LHX3 vs CYTH4 — LSCC

Explore this scatter interactively →