LHX3

Across TCGA patient cohorts, LHX3 mutation is significantly associated with the RNA expression of many other genes, with 372 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LHX3-associated genes across cancer lineages are AFP, RNA5SP436, and PEDS1-UBE2V1. Each is linked with LHX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LHX3-to-partner and partner-to-LHX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AFP grouped by LHX3-low versus LHX3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX3→partner) and Y-score (partner→LHX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	AFP →	+0.976	+3.478	<.001	.002	3	2
UCEC	RNA5SP436 →	+0.237	+3.522	.006	.003	3	2
UCEC	PEDS1-UBE2V1 →	+0.033	+2.751	<.001	.002	3	2
LUSC	MTND6P17 →	+0.103	+7.924	<.001	.008	3	2
SKCM	DEFB136 →	+0.403	+4.138	<.001	.001	3	2
SKCM	MIR1286 →	+0.619	+3.945	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 372 associations by consensus.

AFP by LHX3 expression — SKCM

Explore this box plot interactively →