LHX3

Across TCGA patient cohorts, LHX3 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LHX3-associated genes across cancer lineages are Caspase-7-cleavedD198, ERK2, and JNK2. Each is linked with LHX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LHX3-to-partner and partner-to-LHX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by LHX3-low versus LHX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX3→partner) and Y-score (partner→LHX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.735	+2.827	.032	.035	3	2
UCEC	ERK2 →	+0.241	+3.000	.030	.037	3	1
UCEC	JNK2 →	+0.260	+3.000	.023	.037	1	1
UCEC	Rab25 →	-0.466	-3.000	.015	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Caspase-7-cleavedD198 by LHX3 expression — UCEC

Explore this box plot interactively →