LHX3

Across TCGA cell cohorts, LHX3 RNA expression is significantly associated with the go_rna of many other GO terms, with 647 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LHX3-associated GO terms across cancer lineages are Positive regulation of monoatomic ion transport, Nucleic acid catabolic process, and Regulation of potassium ion transport. Each is linked with LHX3 in more than 5 cancer types. Because this analysis shows association rather than direction, both LHX3-to-partner and partner-to-LHX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of monoatomic ion transport grouped by LHX3-low versus LHX3-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX3→partner) and Y-score (partner→LHX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Positive regulation of monoatomic ion transport →	-0.064	-0.056	.004	.006	3	5
LARGE_INTESTINE	Nucleic acid catabolic process →	+0.024	+0.088	.008	.004	2	6
BONE	Regulation of potassium ion transport →	-0.108	-0.025	<.001	.005	3	5
OESOPHAGUS	RNA splicing, via transesterification reactions →	+0.092	+0.362	<.001	.007	3	4
OESOPHAGUS	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.091	+0.362	<.001	.007	3	4
OESOPHAGUS	mRNA splicing, via spliceosome →	+0.091	+0.362	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 647 associations by consensus.

Positive regulation of monoatomic ion transport by LHX3 expression — PANCREAS

Explore this box plot interactively →