LHX3

Across TCGA cell cohorts, LHX3 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LHX3-associated genes across cancer lineages are OOSP4B, GDF2, and ZNF831. Each is linked with LHX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LHX3-to-partner and partner-to-LHX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OOSP4B grouped by LHX3-low versus LHX3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX3→partner) and Y-score (partner→LHX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OOSP4B →	+0.075	+4.977	<.001	.007	3	1
LUNG_SCLC	GDF2 →	+0.017	+4.643	<.001	.004	3	1
LARGE_INTESTINE	ZNF831 →	+0.010	+2.688	<.001	.008	3	1
LARGE_INTESTINE	EN1 →	+1.193	+3.285	<.001	.007	3	1
BLOOD_Leukemia	CBLN4 →	+0.006	+5.539	<.001	.003	3	1
BLOOD_Lymphoma	OR52L1 →	+0.047	+4.191	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OOSP4B by LHX3 expression — SKIN

Explore this box plot interactively →