LHX1

Across TCGA patient cohorts, LHX1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LHX1-associated genes across cancer lineages are PI3K-p85, RAD51, and 14-3-3_beta. Each is linked with LHX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LHX1-to-partner and partner-to-LHX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PI3K-p85 grouped by LHX1-low versus LHX1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX1→partner) and Y-score (partner→LHX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PI3K-p85 →	-0.172	-2.991	.020	.036	3	2
COAD	RAD51 →	+0.168	+3.008	.040	.019	3	1
UCEC	14-3-3_beta →	-0.126	-2.973	.007	.035	3	1
UCEC	FoxM1 →	+0.320	+3.179	.007	.010	3	1
UCEC	GATA6 →	-0.252	-3.321	<.001	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.187	-2.571	.017	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

PI3K-p85 by LHX1 expression — COAD

Explore this box plot interactively →