LHX1

Across TCGA pan-cancer cohorts, LHX1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated LHX1 data layer compared with 5 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher LHX1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LHX1 expression acts as an unfavorable survival marker, although some lineages such as THCA and READ show a favorable association.

MESO, KIRP, and ACC are the cancer types where LHX1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.412	0.673	<.001	132	view →
KIRP	DFS	Median	All	0.508	0.699	<.001	105	view →
ACC	OS	Tertile	All	0.317	0.746	<.001	91	view →
HNSC	OS	Tertile	All	0.657	0.809	<.001	88	view →
KIRC	OS	Tertile	II,III,IV	0.428	0.639	<.001	73	view →
BRCA	OS	Median	II,III,IV	0.871	0.939	<.001	66	view →
UCEC	OS	Tertile	All	0.801	0.933	<.001	58	view →
UVM	DFS	Quartile	II,III,IV	0.293	0.718	.001	56	view →
SKCM	DFS	Median	All	0.695	0.777	.007	30	view →
SCLC	DFS	Median	III,IV	0.338	0.968	.024	21	view →
THCA	DFS	Quartile	All	0.940	0.793	<.001	18	view →
SARC	OS	Quartile	All	0.374	0.695	.002	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

LHX1–MESO (OS)

Open the MESO breakdown →