LHX1

Across TCGA cell cohorts, LHX1 RNA expression is significantly associated with the RNA expression of many other genes, with 3,996 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible LHX1-associated genes across cancer lineages are AATF, AFAP1L2, and COL18A1. Each is linked with LHX1 in more than 6 cancer types. Because this analysis shows association rather than direction, both LHX1-to-partner and partner-to-LHX1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LHX1 versus AATF in URINARY_TRACT, with a Pearson correlation of 0.52.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX1→partner) and Y-score (partner→LHX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	AATF →	+0.728	+1.559	.001	.002	2	7
OVARY	AFAP1L2 →	+2.860	+2.226	<.001	<.001	3	5
PANCREAS	COL18A1 →	+2.502	+1.751	<.001	<.001	3	4
STOMACH	FSCN1 →	+3.135	+0.944	.001	.003	2	4
KIDNEY	SPSB1 →	+1.295	+1.869	<.001	<.001	3	3
OVARY	RESF1 →	+1.419	+2.229	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,996 associations by consensus.

LHX1 vs AATF — URINARY_TRACT

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