LHX1

Across TCGA cell cohorts, LHX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,849 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible LHX1-associated GO terms across cancer lineages are Vagina development, Spinal cord motor neuron migration, and Lateral motor column neuron migration. Each is linked with LHX1 in more than 11 cancer types. Because this analysis shows association rather than direction, both LHX1-to-partner and partner-to-LHX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vagina development grouped by LHX1-low versus LHX1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX1→partner) and Y-score (partner→LHX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Vagina development →	+1.546	+2.498	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Spinal cord motor neuron migration →	+1.578	+2.537	.002	.004	3	12
LUNG_NSCLC_LUSC	Lateral motor column neuron migration →	+1.578	+2.537	.002	.004	3	12
KIDNEY	Positive regulation of gastrulation →	-0.303	-2.305	<.001	.001	3	11
KIDNEY	Regulation of gastrulation →	-0.215	-1.971	<.001	.003	3	10
OESOPHAGUS	Embryonic viscerocranium morphogenesis →	-0.264	-1.321	.002	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,849 associations by consensus.

Vagina development by LHX1 expression — OVARY

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