LHX1

Across TCGA cell cohorts, LHX1 mutation is significantly associated with the RNA expression of many other genes, with 1,160 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LHX1-associated genes across cancer lineages are IL31, OR51B6, and PES1. Each is linked with LHX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LHX1-to-partner and partner-to-LHX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL31 grouped by LHX1-low versus LHX1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX1→partner) and Y-score (partner→LHX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	IL31 →	+0.024	+4.981	<.001	.008	3	1
OVARY	OR51B6 →	+0.110	+4.263	<.001	.002	3	1
LARGE_INTESTINE	PES1 →	+0.443	+2.916	.007	<.001	3	1
LARGE_INTESTINE	ANKRD54 →	+0.511	+2.829	<.001	<.001	3	1
LARGE_INTESTINE	EIF3L →	+0.639	+3.546	<.001	<.001	3	1
LARGE_INTESTINE	CCDC134 →	+0.775	+3.453	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,160 associations by consensus.

IL31 by LHX1 expression — CNS

Explore this box plot interactively →