LHX1-DT

Across TCGA pan-cancer cohorts, LHX1-DT RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated LHX1-DT data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher LHX1-DT RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LHX1-DT expression acts as an unfavorable survival marker, although some lineages such as KICH and ESCA show a favorable association.

ACC, HNSC, and MESO are the cancer types where LHX1-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.310	0.743	<.001	127	view →
HNSC	OS	Median	All	0.695	0.804	<.001	120	view →
MESO	DFS	Quartile	IV	0.079	0.468	<.001	93	view →
KIRC	DFS	Quartile	All	0.699	0.873	.003	70	view →
KIRP	OS	Tertile	II,III,IV	0.242	0.747	<.001	63	view →
BRCA	OS	Median	All	0.889	0.944	<.001	48	view →
UCEC	DFS	Quartile	All	0.732	0.860	.001	38	view →
LGG	DFS	Median	All	0.304	0.515	<.001	26	view →
COAD	OS	Tertile	IV	0.232	0.618	.015	24	view →
BLCA	DFS	Median	All	0.567	0.679	.018	23	view →
STAD	OS	Quartile	All	0.518	0.763	.012	12	view →
TGCT	DFS	Median	All	0.750	0.909	.019	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

LHX1-DT–ACC (OS)

Open the ACC breakdown →