LHX1-DT

Across TCGA pan-cancer cohorts, LHX1-DT RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of LHX1-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LHX1-DT RNA is repressed in tumor relative to normal tissue. In most cancer types LHX1-DT is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, HNSC, and KICH are the cancer types where LHX1-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LHX1-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	−3.739	<.001	12	view →
HNSC	Female	III,IV	+1.044	<.001	12	view →
KICH	Female	II,III,IV	−4.430	<.001	11	view →
KIRP	Male	All	−3.682	<.001	11	view →
LUAD	All	All	+0.301	<.001	6	view →
BRCA	All	II,III,IV	+0.239	<.001	6	view →
LUSC	Male	All	+0.300	.001	4	view →
BLCA	All	III,IV	+0.482	.048	2	view →
PRAD	All	All	−0.252	.005	2	view →
LIHC	Female	All	+0.004	.040	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

LHX1-DT–KIRC

Open the KIRC breakdown →