Across TCGA patient cohorts, LHFPL6 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LHFPL6-associated genes across cancer lineages are 4E-BP1, Notch1, and 4E-BP1_pT37_T46. Each is linked with LHFPL6 in more than 2 cancer types. Because this analysis shows association rather than direction, both LHFPL6-to-partner and partner-to-LHFPL6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHFPL6→partner) and Y-score (partner→LHFPL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.272	+2.351	.012	.018	3	3
UCEC	Notch1 →	+0.137	+1.906	.015	.016	3	2
UCEC	4E-BP1_pT37_T46 →	-0.394	-3.308	.009	.009	3	2
UCEC	IGFBP2 →	-0.753	-1.906	.003	.016	3	1
UCEC	PCNA →	+0.265	+1.906	.002	.016	3	1
UCEC	PDK1_pS241 →	+0.149	+2.584	.030	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

LHFPL6 survival (RNA) · tumor vs normal (RNA) · all LHFPL6 data types