Across TCGA pan-cancer cohorts, LHFPL6 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of LHFPL6’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where LHFPL6 RNA is repressed in tumor relative to normal tissue. In most cancer types LHFPL6 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.
LUAD, LUSC, and KICH are the cancer types where LHFPL6 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LHFPL6 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.