LHFPL4

Across TCGA patient cohorts, LHFPL4 mutation is significantly associated with the RNA expression of many other genes, with 2,500 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LHFPL4-associated genes across cancer lineages are H2AC14, CNTROB, and RNU6-1308P. Each is linked with LHFPL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LHFPL4-to-partner and partner-to-LHFPL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2AC14 grouped by LHFPL4-low versus LHFPL4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHFPL4→partner) and Y-score (partner→LHFPL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	H2AC14 →	+0.817	+2.823	<.001	.001	3	2
UCEC	CNTROB →	+0.368	+2.595	.006	.005	3	2
CESC	RNU6-1308P →	+0.344	+4.144	<.001	.009	3	2
CESC	MTND4LP20 →	+0.088	+5.164	<.001	.002	3	2
BRCA	RNU6-206P →	+0.400	+5.201	<.001	.002	3	2
UCEC	CCDC9 →	+0.502	+3.180	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,500 associations by consensus.

H2AC14 by LHFPL4 expression — UCEC

Explore this box plot interactively →