LHCGR

Across TCGA patient cohorts, LHCGR protein abundance is significantly associated with the RNA expression of many other genes, with 7,853 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LHCGR-associated genes across cancer lineages are ZFHX3, IL27RA, and DENND3. Each is linked with LHCGR in more than 3 cancer types. Because this analysis shows association rather than direction, both LHCGR-to-partner and partner-to-LHCGR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LHCGR versus ZFHX3 in LSCC, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHCGR→partner) and Y-score (partner→LHCGR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZFHX3 →	+0.794	+0.512	<.001	.006	3	4
BRCA	IL27RA →	-1.095	-0.498	.002	.003	3	3
UCEC	DENND3 →	-0.653	-0.457	<.001	.005	3	3
UCEC	CEACAM4 →	-0.634	-0.566	.003	.001	3	3
LSCC	VSIR →	-0.854	-0.613	<.001	<.001	3	3
UCEC	FAM20A →	-0.787	-0.506	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,853 associations by consensus.

LHCGR vs ZFHX3 — LSCC

Explore this scatter interactively →