LHCGR

Across TCGA pan-cancer cohorts, LHCGR RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated LHCGR data layer compared with 9 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher LHCGR RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated LHCGR expression acts as an unfavorable survival marker, although some lineages such as KIRP and SKCM show a favorable association.

KIRP, READ, and SKCM are the cancer types where LHCGR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	II,III,IV	0.866	0.515	<.001	88	view →
READ	DFS	Tertile	IV	0.073	0.674	<.001	60	view →
SKCM	OS	Tertile	All	0.422	0.296	<.001	42	view →
KIRC	DFS	Quartile	II,III,IV	0.574	0.717	.011	34	view →
UVM	DFS	Tertile	III,IV	0.090	0.711	.018	31	view →
LUAD	DFS	Quartile	All	0.890	0.704	.004	21	view →
OV	DFS	Quartile	IV	0.595	0.315	.012	20	view →
THYM	DFS	Tertile	III,IV	0.468	0.865	.006	15	view →
COAD	OS	Tertile	II,III,IV	0.728	0.880	.025	15	view →
UCS	OS	Tertile	IV	0.205	0.675	.024	12	view →
PCPG	DFS	Quartile	All	0.977	0.811	.013	11	view →
SCLC	DFS	Quartile	All	1.000	0.426	.014	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

LHCGR–KIRP (DFS)

Open the KIRP breakdown →