LHCGR

Across TCGA cell cohorts, LHCGR mutation is significantly associated with the RNA expression of many other genes, with 473 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LHCGR-associated genes across cancer lineages are OR6V1, OR56A5, and SCYGR10. Each is linked with LHCGR in more than 1 cancer types. Because this analysis shows association rather than direction, both LHCGR-to-partner and partner-to-LHCGR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6V1 grouped by LHCGR-low versus LHCGR-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHCGR→partner) and Y-score (partner→LHCGR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR6V1 →	+0.014	+3.169	<.001	.008	3	2
UPPER_AERODIGESTIVE_TRACT	OR56A5 →	+0.035	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	SCYGR10 →	+0.180	+5.357	<.001	.003	3	2
SKIN	EEF1A1 →	+0.640	+3.169	<.001	.009	3	2
LARGE_INTESTINE	LANCL1 →	+0.732	+3.067	.004	.009	3	2
LARGE_INTESTINE	ZCCHC2 →	+0.786	+2.628	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 473 associations by consensus.

OR6V1 by LHCGR expression — BLOOD_Lymphoma

Explore this box plot interactively →