LGSN

Across TCGA cell cohorts, LGSN mutation is significantly associated with the RNA expression of many other genes, with 61 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LGSN-associated genes across cancer lineages are NXPE4, SCML2, and RAI1. Each is linked with LGSN in more than 1 cancer types. Because this analysis shows association rather than direction, both LGSN-to-partner and partner-to-LGSN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NXPE4 grouped by LGSN-low versus LGSN-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGSN→partner) and Y-score (partner→LGSN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NXPE4 →	+0.010	+3.106	.007	.005	3	2
LARGE_INTESTINE	SCML2 →	+1.031	+3.067	.006	.009	3	1
LARGE_INTESTINE	RAI1 →	+0.870	+3.064	.004	.009	3	1
LARGE_INTESTINE	PCCB →	+0.780	+3.125	<.001	.008	3	1
LARGE_INTESTINE	AGPAT5 →	+0.779	+3.082	.001	.007	3	1
LARGE_INTESTINE	CALML5 →	+0.824	+3.584	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

NXPE4 by LGSN expression — BLOOD_Leukemia

Explore this box plot interactively →