LGR4-AS1

Across TCGA pan-cancer cohorts, LGR4-AS1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated LGR4-AS1 data layer.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher LGR4-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated LGR4-AS1 expression acts as an unfavorable survival marker, although some lineages such as OV and BRCA show a favorable association.

OV, BRCA, and READ are the cancer types where LGR4-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	All	0.893	0.786	.001	50	view →
BRCA	OS	Quartile	II,III,IV	0.938	0.866	.003	49	view →
READ	DFS	Tertile	All	0.700	0.388	.002	43	view →
LIHC	DFS	Quartile	All	0.363	0.630	<.001	34	view →
BLCA	DFS	Quartile	All	0.638	0.410	<.001	33	view →
LUSC	OS	Median	All	0.832	0.719	<.001	29	view →
LGG	DFS	Median	All	0.791	0.866	.001	29	view →
KIRP	OS	Tertile	All	0.965	0.871	.005	27	view →
THCA	DFS	Tertile	All	0.876	0.712	.001	26	view →
GBM	OS	Median	All	0.207	0.323	.010	14	view →
MESO	OS	Tertile	II,III,IV	0.689	0.459	.008	13	view →
HNSC	OS	Tertile	IV	0.790	0.628	.028	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

LGR4-AS1–OV (OS)

Open the OV breakdown →