LGR4-AS1

Across TCGA pan-cancer cohorts, LGR4-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of LGR4-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where LGR4-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types LGR4-AS1 is over-expressed in tumor, although a few such as COAD and KIRC show the opposite, repressed pattern.

COAD, KIRC, and BRCA are the cancer types where LGR4-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LGR4-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.268	<.001	8	view →
KIRC	All	II,III,IV	−0.143	.001	8	view →
BRCA	All	III,IV	−1.161	<.001	6	view →
LUAD	All	All	+0.231	<.001	5	view →
LIHC	All	All	+0.048	.003	5	view →
CHOL	Male	All	+0.206	.026	4	view →
THCA	Male	III,IV	−0.452	.003	3	view →
HNSC	Female	II,III,IV	−0.110	.013	3	view →
LUSC	All	All	+0.065	.006	3	view →
READ	All	All	−0.246	.034	2	view →
UCEC	All	All	−0.205	.030	2	view →
STAD	All	All	+0.097	.035	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

LGR4-AS1–COAD

Open the COAD breakdown →