LGMN

Across TCGA pan-cancer cohorts, LGMN mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated LGMN data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher LGMN mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated LGMN expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

COAD, HNSC, and LSCC are the cancer types where LGMN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.826	1.000	.023	42	view →
HNSC	DFS	Tertile	II,III,IV	0.455	0.792	.002	10	view →
LSCC	OS	Median	III,IV	1.000	0.721	.002	8	view →
PDAC	DFS	Median	All	0.857	0.733	.006	6	view →
UCEC	DFS	Median	II,III,IV	0.509	0.867	.033	4	view →
GBM	DFS	Median	All	0.303	0.444	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

LGMN–COAD (DFS)

Open the COAD breakdown →