LGI3

Across TCGA patient cohorts, LGI3 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,176 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LGI3-associated proteins across cancer lineages are ALDH1A1, GDA, and GSTM3. Each is linked with LGI3 in more than 3 cancer types. Because this analysis shows association rather than direction, both LGI3-to-partner and partner-to-LGI3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LGI3 versus ALDH1A1 in GBM, with a Pearson correlation of 0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LGI3→partner) and Y-score (partner→LGI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ALDH1A1 →	+0.625	+1.816	<.001	<.001	3	4
LSCC	GDA →	+0.998	+0.805	<.001	.002	3	4
LSCC	GSTM3 →	+1.006	+0.802	.001	<.001	3	4
GBM	TPPP →	+1.109	+2.271	<.001	<.001	3	3
GBM	TPPP_T14 →	+1.072	+2.019	<.001	<.001	3	3
GBM	TRIM2 →	+0.508	+1.807	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,176 associations by consensus.

LGI3 vs ALDH1A1 — GBM

Explore this scatter interactively →