LGI3

Across TCGA patient cohorts, LGI3 mutation is significantly associated with the RNA expression of many other genes, with 933 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LGI3-associated genes across cancer lineages are GOT2, TRIM36, and MRPL39. Each is linked with LGI3 in more than 2 cancer types. Because this analysis shows association rather than direction, both LGI3-to-partner and partner-to-LGI3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GOT2 grouped by LGI3-low versus LGI3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGI3→partner) and Y-score (partner→LGI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GOT2 →	+0.433	+3.700	<.001	.001	3	3
UCEC	TRIM36 →	+0.758	+2.137	<.001	.001	3	2
UCEC	MRPL39 →	+0.406	+3.753	.001	<.001	3	2
UCEC	PKN3 →	+0.576	+2.147	<.001	.009	3	2
UCEC	SKA3 →	+0.556	+2.158	.002	<.001	3	2
UCEC	CENPN →	+0.586	+2.828	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 933 associations by consensus.

GOT2 by LGI3 expression — UCEC

Explore this box plot interactively →