LGI2

Across TCGA cell cohorts, LGI2 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible LGI2-associated genes across cancer lineages are KLHL40, CST9, and OR9A2. Each is linked with LGI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LGI2-to-partner and partner-to-LGI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL40 grouped by LGI2-low versus LGI2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGI2→partner) and Y-score (partner→LGI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KLHL40 →	+0.013	+5.209	<.001	.005	3	2
BLOOD_Lymphoma	CST9 →	+0.119	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	OR9A2 →	+0.022	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	MRGPRG →	+0.056	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	VN1R2 →	+0.006	+5.643	.003	.002	3	1
BLOOD_Lymphoma	OR14A16 →	+0.023	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

KLHL40 by LGI2 expression — BLOOD_Lymphoma

Explore this box plot interactively →