LGI1

Across TCGA patient cohorts, LGI1 protein abundance is significantly associated with the RNA expression of many other genes, with 3,161 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LGI1-associated genes across cancer lineages are PRODH, PIK3IP1, and SOX10. Each is linked with LGI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LGI1-to-partner and partner-to-LGI1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LGI1 versus PRODH in GBM, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGI1→partner) and Y-score (partner→LGI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRODH →	+1.066	+0.829	<.001	<.001	3	1
GBM	PIK3IP1 →	+0.643	+0.549	.003	.009	3	1
GBM	SOX10 →	+1.923	+0.781	<.001	<.001	3	1
GBM	SLC16A8 →	+0.378	+0.564	.003	<.001	3	1
GBM	SEPTIN3 →	+0.814	+0.801	.001	<.001	3	1
GBM	SUN2 →	+0.447	+0.694	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,161 associations by consensus.

LGI1 vs PRODH — GBM

Explore this scatter interactively →