LGI1

Across TCGA cell cohorts, LGI1 RNA expression is significantly associated with the mutation status of many other genes, with 228 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LGI1-associated genes across cancer lineages are SVEP1, ZNF423, and LRRIQ1. Each is linked with LGI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LGI1-to-partner and partner-to-LGI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SVEP1 grouped by LGI1-low versus LGI1-high in BLOOD_Leukemia.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGI1→partner) and Y-score (partner→LGI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SVEP1 →	+3.539	+0.043	.002	<.001	3	2
BLOOD_Leukemia	ZNF423 →	+3.802	+0.049	.001	<.001	3	2
BLOOD_Leukemia	LRRIQ1 →	+3.124	+0.035	.004	.002	3	2
BLOOD_Leukemia	APC →	+3.124	+0.035	.004	.002	3	2
BLOOD_Leukemia	CELSR2 →	+3.369	+0.035	<.001	.001	3	2
BLOOD_Leukemia	TBC1D32 →	+4.539	+0.096	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 228 associations by consensus.

SVEP1 by LGI1 expression — BLOOD_Leukemia

Explore this box plot interactively →