LGALS9B

Across TCGA patient cohorts, LGALS9B mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LGALS9B-associated genes across cancer lineages are Notch1, Caspase-7-cleavedD198, and Gab2. Each is linked with LGALS9B in more than 1 cancer types. Because this analysis shows association rather than direction, both LGALS9B-to-partner and partner-to-LGALS9B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by LGALS9B-low versus LGALS9B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGALS9B→partner) and Y-score (partner→LGALS9B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.230	+2.469	<.001	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.650	+2.999	.012	.035	3	2
UCEC	Gab2 →	+0.316	+2.115	.043	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.146	-2.102	.046	.019	3	1
UCEC	JNK2 →	+0.294	+2.115	<.001	.019	3	1
UCEC	Ku80 →	+0.273	+2.128	.008	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Notch1 by LGALS9B expression — UCEC

Explore this box plot interactively →