LGALS9B

Across TCGA pan-cancer cohorts, LGALS9B RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of LGALS9B’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where LGALS9B RNA is repressed in tumor relative to normal tissue. In most cancer types LGALS9B is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, KIRC, and KIRP are the cancer types where LGALS9B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LGALS9B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−1.866	<.001	11	view →
KIRC	Female	All	+0.080	<.001	11	view →
KIRP	Male	II,III,IV	+0.051	<.001	8	view →
READ	Male	All	−3.170	.001	6	view →
BRCA	All	II,III,IV	+0.319	<.001	6	view →
STAD	All	All	−1.117	.011	4	view →
CHOL	All	All	+0.524	.005	3	view →
ESCA	All	II,III,IV	−1.285	.010	2	view →
PRAD	All	All	−0.134	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

LGALS9B–COAD

Open the COAD breakdown →