LGALS9

Across TCGA patient cohorts, LGALS9 mutation is significantly associated with the RNA expression of many other genes, with 887 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LGALS9-associated genes across cancer lineages are LINC02353, IGKV3-34, and LINC01707. Each is linked with LGALS9 in more than 1 cancer types. Because this analysis shows association rather than direction, both LGALS9-to-partner and partner-to-LGALS9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02353 grouped by LGALS9-low versus LGALS9-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGALS9→partner) and Y-score (partner→LGALS9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LINC02353 →	+0.038	+4.669	<.001	.007	3	2
CESC	IGKV3-34 →	+0.115	+5.342	<.001	.002	3	2
COAD	LINC01707 →	+0.231	+5.693	<.001	.003	3	2
UCEC	BAG3 →	+0.698	+3.000	<.001	.001	3	2
UCEC	NCAPH2 →	+0.550	+3.601	<.001	.001	3	2
UCEC	AP3D1 →	+0.477	+3.201	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 887 associations by consensus.

LINC02353 by LGALS9 expression — CESC

Explore this box plot interactively →