LGALS8

Across TCGA patient cohorts, LGALS8 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LGALS8-associated genes across cancer lineages are EGFR_pY1068, EGFR, and eIF4E. Each is linked with LGALS8 in more than 1 cancer types. Because this analysis shows association rather than direction, both LGALS8-to-partner and partner-to-LGALS8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by LGALS8-low versus LGALS8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGALS8→partner) and Y-score (partner→LGALS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.214	-1.906	.034	.016	3	1
UCEC	EGFR →	-0.247	-3.584	<.001	.002	3	1
UCEC	eIF4E →	+0.234	+3.472	.005	.002	3	1
UCEC	eIF4G →	+0.268	+3.169	.032	.019	3	1
UCEC	INPP4B →	-0.259	-3.321	.047	.009	3	1
UCEC	Ku80 →	+0.358	+2.428	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

EGFR_pY1068 by LGALS8 expression — UCEC

Explore this box plot interactively →