LGALS7B

Across TCGA cell cohorts, LGALS7B protein abundance is significantly associated with the go_rna of many other GO terms, with 458 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible LGALS7B-associated GO terms across cancer lineages are Negative regulation of type I interferon-mediated signaling pathway, Hypersensitivity, and Cytotoxic T cell degranulation. Each is linked with LGALS7B in more than 2 cancer types. Because this analysis shows association rather than direction, both LGALS7B-to-partner and partner-to-LGALS7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of type I interferon-mediated signaling pathway grouped by LGALS7B-low versus LGALS7B-high in OESOPHAGUS.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LGALS7B→partner) and Y-score (partner→LGALS7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of type I interferon-mediated signaling pathway →	-0.224	-5.802	.004	<.001	3	2
LUNG_NSCLC_LUAD	Hypersensitivity →	-0.382	-3.483	.005	<.001	3	2
LUNG_NSCLC_LUAD	Cytotoxic T cell degranulation →	-0.429	-3.849	<.001	<.001	3	2
LUNG_NSCLC_LUAD	Sensory perception of sweet taste →	-0.192	-3.483	.006	<.001	3	2
LUNG_NSCLC_LUAD	Sensory perception of umami taste →	-0.170	-3.483	.006	<.001	3	2
LUNG_NSCLC_LUAD	Cardiac vascular smooth muscle cell differentiation →	-0.295	-3.483	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 458 associations by consensus.

Negative regulation of type I interferon-mediated signaling pathway by LGALS7B expression — OESOPHAGUS

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