LGALS7B

Across TCGA pan-cancer cohorts, LGALS7B RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated LGALS7B data layer compared with 1 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher LGALS7B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LGALS7B expression acts as an unfavorable survival marker, although some lineages such as THCA and ESCA show a favorable association.

UVM, UCEC, and THCA are the cancer types where LGALS7B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	II,III,IV	0.340	0.688	<.001	78	view →
UCEC	OS	Median	All	0.543	0.841	<.001	62	view →
THCA	OS	Median	II,III,IV	1.000	0.326	.002	43	view →
BLCA	DFS	Tertile	II,III,IV	0.207	0.413	.006	42	view →
SKCM	OS	Quartile	All	0.665	0.826	<.001	40	view →
ESCA	OS	Median	IV	0.698	0.222	.006	22	view →
KIRC	DFS	Tertile	IV	0.616	0.311	.016	16	view →
ACC	DFS	Tertile	II,III,IV	0.882	0.398	.012	15	view →
PAAD	OS	Quartile	All	0.346	0.703	.005	12	view →
LUAD	OS	Median	III,IV	0.769	0.562	.011	10	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	8	view →
UCS	DFS	Tertile	III,IV	0.548	0.149	.022	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

LGALS7B–UVM (DFS)

Open the UVM breakdown →