LGALS4

Across TCGA pan-cancer cohorts, LGALS4 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of LGALS4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where LGALS4 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types LGALS4 is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

COAD, LSCC, and PDAC are the cancer types where LGALS4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LGALS4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−0.895	<.001	11	view →
LSCC	Male	II,III,IV	−1.378	<.001	8	view →
PDAC	Female	All	+0.809	<.001	8	view →
CCRCC	Female	All	+0.962	.046	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

LGALS4–COAD

Open the COAD breakdown →