LGALS4

Across TCGA pan-cancer cohorts, LGALS4 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated LGALS4 data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher LGALS4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LGALS4 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

ACC, KIRC, and KIRP are the cancer types where LGALS4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.353	0.809	<.001	164	view →
KIRC	DFS	Median	IV	0.621	0.368	<.001	60	view →
KIRP	DFS	Quartile	All	0.733	0.904	.001	52	view →
UCS	DFS	Tertile	III,IV	0.639	0.091	.001	38	view →
MESO	OS	Quartile	All	0.258	0.668	.006	37	view →
COAD	DFS	Median	III,IV	0.806	0.585	.005	28	view →
BLCA	OS	Quartile	II,III,IV	0.816	0.634	.001	22	view →
ESCA	OS	Median	All	0.617	1.000	.009	21	view →
CHOL	OS	Tertile	All	0.897	0.498	.003	20	view →
LGG	DFS	Quartile	All	0.645	0.856	<.001	19	view →
PRAD	DFS	Median	All	0.843	0.923	.003	18	view →
READ	DFS	Median	IV	0.936	0.179	.010	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

LGALS4–ACC (DFS)

Open the ACC breakdown →