LGALS4

Across TCGA patient cohorts, LGALS4 mutation is significantly associated with the RNA expression of many other genes, with 2,323 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LGALS4-associated genes across cancer lineages are WDR76, RPL23AP82, and LINC02676. Each is linked with LGALS4 in more than 2 cancer types. Because this analysis shows association rather than direction, both LGALS4-to-partner and partner-to-LGALS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDR76 grouped by LGALS4-low versus LGALS4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGALS4→partner) and Y-score (partner→LGALS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	WDR76 →	+0.783	+2.269	<.001	.001	3	3
UCEC	RPL23AP82 →	+0.459	+3.721	<.001	<.001	3	3
LUSC	LINC02676 →	+0.583	+5.151	<.001	.007	3	3
COAD	RNA5SP66 →	+0.242	+4.602	<.001	.003	3	3
UCEC	CCL4L2 →	+0.831	+2.238	.001	.006	3	2
UCEC	CCL3L3 →	+0.724	+2.246	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,323 associations by consensus.

WDR76 by LGALS4 expression — UCEC

Explore this box plot interactively →