LGALS4

Across TCGA cell cohorts, LGALS4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,786 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LGALS4-associated GO terms across cancer lineages are Negative regulation of autophagy, Regulation of RNA splicing, and Glycerolipid biosynthetic process. Each is linked with LGALS4 in more than 7 cancer types. Because this analysis shows association rather than direction, both LGALS4-to-partner and partner-to-LGALS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of autophagy grouped by LGALS4-low versus LGALS4-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LGALS4→partner) and Y-score (partner→LGALS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of autophagy →	+0.073	+0.461	<.001	.003	3	8
SOFT_TISSUE	Regulation of RNA splicing →	+0.059	+0.550	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Glycerolipid biosynthetic process →	+0.040	+0.407	<.001	<.001	3	8
BREAST	Macroautophagy →	+0.040	+0.433	.001	.007	3	8
SOFT_TISSUE	Regulatory ncRNA-mediated gene silencing →	+0.085	+0.757	.001	.001	3	7
STOMACH	Response to progesterone →	+0.130	+4.455	.006	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,786 associations by consensus.

Negative regulation of autophagy by LGALS4 expression — UPPER_AERODIGESTIVE_TRACT

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