LGALS12

Across TCGA patient cohorts, LGALS12 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LGALS12-associated genes across cancer lineages are ASNS, PDK1, and PDK1_pS241. Each is linked with LGALS12 in more than 1 cancer types. Because this analysis shows association rather than direction, both LGALS12-to-partner and partner-to-LGALS12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by LGALS12-low versus LGALS12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LGALS12→partner) and Y-score (partner→LGALS12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.457	+3.000	.029	.037	3	1
SKCM	PDK1 →	-0.142	-2.270	.008	.035	3	1
SKCM	PDK1_pS241 →	-0.191	-2.304	.020	.035	2	1
UCEC	HER3 →	-0.385	-2.986	.015	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ASNS by LGALS12 expression — UCEC

Explore this box plot interactively →