LFNG

Across TCGA patient cohorts, LFNG protein abundance is significantly associated with the RNA expression of many other genes, with 6,252 significant associations in total. COAD shows the largest number of these associations.

The most reproducible LFNG-associated genes across cancer lineages are IQCE, CYP3A5, and SH3BP4. Each is linked with LFNG in more than 3 cancer types. Because this analysis shows association rather than direction, both LFNG-to-partner and partner-to-LFNG results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LFNG versus IQCE in BRCA, with a Pearson correlation of 0.26.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LFNG→partner) and Y-score (partner→LFNG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IQCE →	+0.636	+0.433	<.001	.007	3	3
LUAD	CYP3A5 →	+0.909	+0.451	.002	.006	3	3
BRCA	SH3BP4 →	+0.878	+0.586	<.001	.001	3	3
BRCA	CTDSP1 →	+0.611	+0.501	<.001	<.001	3	3
GBM	TCTN2 →	+0.554	+0.432	<.001	.002	3	3
BRCA	GP2 →	+1.427	+0.399	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,252 associations by consensus.

LFNG vs IQCE — BRCA

Explore this scatter interactively →