LFNG

Across TCGA pan-cancer cohorts, LFNG RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of LFNG’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LFNG RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LFNG is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where LFNG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LFNG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+1.115	<.001	11	view →
KIRC	Female	All	+0.795	<.001	11	view →
COAD	All	IV	+1.558	<.001	10	view →
KICH	Female	All	−2.169	<.001	8	view →
STAD	Male	II,III,IV	+1.832	<.001	7	view →
LUSC	Male	III,IV	−2.027	<.001	6	view →
LIHC	Female	II,III,IV	+1.042	<.001	6	view →
LUAD	All	II,III,IV	+0.975	<.001	6	view →
CHOL	Male	All	+2.995	<.001	3	view →
PAAD	All	All	+1.235	.045	2	view →
PRAD	All	All	+1.107	<.001	2	view →
READ	Female	All	+0.963	.037	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

LFNG–HNSC

Open the HNSC breakdown →