LEXM

Across TCGA patient cohorts, LEXM mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LEXM-associated genes across cancer lineages are EGFR_pY1068, p38-MAPK_pT180_Y182, and SF2. Each is linked with LEXM in more than 1 cancer types. Because this analysis shows association rather than direction, both LEXM-to-partner and partner-to-LEXM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by LEXM-low versus LEXM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEXM→partner) and Y-score (partner→LEXM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.289	-3.169	.022	.019	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.722	-3.169	.001	.019	2	2
UCEC	SF2 →	+0.112	+2.834	.041	.034	3	1
UCEC	Src_pY527 →	-0.540	-3.159	.012	.019	3	1
UCEC	Src →	+0.208	+2.321	.043	.035	3	1
UCEC	STAT3_pY705 →	-0.514	-3.459	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

EGFR_pY1068 by LEXM expression — UCEC

Explore this box plot interactively →