LEXM

Across TCGA pan-cancer cohorts, LEXM RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of LEXM’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LEXM RNA is repressed in tumor relative to normal tissue. In most cancer types LEXM is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, COAD, and KICH are the cancer types where LEXM tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LEXM RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	−1.655	<.001	12	view →
COAD	Female	All	−1.198	<.001	11	view →
KICH	Male	All	−0.263	<.001	9	view →
KIRC	All	All	+0.085	.006	8	view →
READ	Male	All	−1.273	<.001	6	view →
LIHC	Male	All	+0.303	<.001	6	view →
THCA	All	All	−0.056	<.001	5	view →
BLCA	Male	III,IV	+0.544	<.001	4	view →
BRCA	All	II,III,IV	+0.152	.004	4	view →
PAAD	All	All	+0.772	.010	2	view →
LUSC	All	All	+0.211	.015	2	view →
STAD	All	II,III,IV	−0.816	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

LEXM–HNSC

Open the HNSC breakdown →