LEXM

Across TCGA cell cohorts, LEXM RNA expression is significantly associated with the go_rna of many other GO terms, with 1,773 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible LEXM-associated GO terms across cancer lineages are Chromosome attachment to the nuclear envelope, Positive regulation of regulated secretory pathway, and Negative regulation of NK T cell activation. Each is linked with LEXM in more than 6 cancer types. Because this analysis shows association rather than direction, both LEXM-to-partner and partner-to-LEXM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chromosome attachment to the nuclear envelope grouped by LEXM-low versus LEXM-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LEXM→partner) and Y-score (partner→LEXM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Chromosome attachment to the nuclear envelope →	+0.170	+0.187	.003	.001	3	7
LUNG_SCLC	Positive regulation of regulated secretory pathway →	+0.097	+0.097	<.001	<.001	3	6
BLOOD_Lymphoma	Negative regulation of NK T cell activation →	+0.634	+0.258	<.001	.001	3	6
OESOPHAGUS	Response to toxic substance →	+0.092	+0.286	<.001	<.001	3	6
LIVER	Cellular response to fatty acid →	+0.198	+0.101	.004	<.001	2	7
OESOPHAGUS	Monocarboxylic acid catabolic process →	+0.083	+0.228	<.001	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,773 associations by consensus.

Chromosome attachment to the nuclear envelope by LEXM expression — OESOPHAGUS

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