LETM2

Across TCGA cell cohorts, LETM2 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LETM2-associated genes across cancer lineages are SSMEM1, GPR171, and FAM205C. Each is linked with LETM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LETM2-to-partner and partner-to-LETM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSMEM1 grouped by LETM2-low versus LETM2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LETM2→partner) and Y-score (partner→LETM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SSMEM1 →	+0.023	+4.029	.003	.002	3	1
LARGE_INTESTINE	GPR171 →	+0.017	+3.688	<.001	.002	3	1
LARGE_INTESTINE	FAM205C →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	FAM205A →	+0.019	+3.766	.001	.004	3	1
LARGE_INTESTINE	BHLHA9 →	+0.216	+3.510	<.001	.003	3	1
LARGE_INTESTINE	CCL18 →	+0.066	+4.415	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

SSMEM1 by LETM2 expression — LARGE_INTESTINE

Explore this box plot interactively →