LERFS

Across TCGA patient cohorts, LERFS RNA expression is significantly associated with the go_rna of many other GO terms, with 4,590 significant associations in total. STAD shows the largest number of these associations.

The most reproducible LERFS-associated GO terms across cancer lineages are Mitochondrial respiratory chain complex assembly, Protein targeting to mitochondrion, and Protein transmembrane transport. Each is linked with LERFS in more than 8 cancer types. Because this analysis shows association rather than direction, both LERFS-to-partner and partner-to-LERFS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial respiratory chain complex assembly grouped by LERFS-low versus LERFS-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LERFS→partner) and Y-score (partner→LERFS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Mitochondrial respiratory chain complex assembly →	+0.044	+0.207	<.001	<.001	3	8
STAD	Protein targeting to mitochondrion →	+0.053	+0.258	<.001	.001	3	8
STAD	Protein transmembrane transport →	+0.042	+0.185	<.001	<.001	3	8
STAD	Positive regulation of amide metabolic process →	+0.053	+0.255	<.001	<.001	3	7
STAD	7-methylguanosine cap hypermethylation →	+0.057	+0.302	<.001	<.001	3	7
STAD	Protein localization to mitochondrion →	+0.053	+0.292	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,590 associations by consensus.

Mitochondrial respiratory chain complex assembly by LERFS expression — STAD

Explore this box plot interactively →