LERFS

Across TCGA pan-cancer cohorts, LERFS RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of LERFS’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where LERFS RNA is repressed in tumor relative to normal tissue. In most cancer types LERFS is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KICH and BLCA are the cancer types where LERFS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LERFS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−0.101	.002	4	view →
BLCA	Female	IV	+0.093	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

LERFS–KICH

Open the KICH breakdown →