LENG8

Across TCGA patient cohorts, LENG8 mutation is significantly associated with the RNA expression of many other genes, with 6,739 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LENG8-associated genes across cancer lineages are HMG20B, LINC01941, and RNU6-171P. Each is linked with LENG8 in more than 3 cancer types. Because this analysis shows association rather than direction, both LENG8-to-partner and partner-to-LENG8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMG20B grouped by LENG8-low versus LENG8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LENG8→partner) and Y-score (partner→LENG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HMG20B →	+0.435	+2.684	<.001	<.001	3	4
CESC	LINC01941 →	+0.106	+3.932	<.001	.002	3	3
LIHC	RNU6-171P →	+0.251	+5.317	<.001	.002	3	3
LUAD	SPATA31A1 →	+0.024	+4.399	<.001	.008	3	3
COAD	SENP3-EIF4A1 →	+0.201	+2.688	<.001	.004	3	3
UCEC	ALDOA →	+0.346	+2.415	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,739 associations by consensus.

HMG20B by LENG8 expression — UCEC

Explore this box plot interactively →