LENG8

Across TCGA cell cohorts, LENG8 mutation is significantly associated with the RNA expression of many other genes, with 91 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LENG8-associated genes across cancer lineages are KLHL2, PDCD2L, and CLEC4C. Each is linked with LENG8 in more than 1 cancer types. Because this analysis shows association rather than direction, both LENG8-to-partner and partner-to-LENG8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL2 grouped by LENG8-low versus LENG8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LENG8→partner) and Y-score (partner→LENG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KLHL2 →	+0.681	+3.169	.001	.009	3	1
LARGE_INTESTINE	PDCD2L →	+0.436	+3.169	.006	.009	3	1
LUNG_NSCLC_LUAD	CLEC4C →	+0.039	+4.947	<.001	.001	3	1
SKIN	AVPR1B →	+0.009	+4.415	<.001	.007	3	1
BLOOD_Leukemia	CRYBA2 →	+0.342	+4.234	<.001	.003	3	1
BLOOD_Leukemia	SSMEM1 →	+0.059	+4.254	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 91 associations by consensus.

KLHL2 by LENG8 expression — LARGE_INTESTINE

Explore this box plot interactively →